We have experience in the field of gene analysis with use of DNA micro arrays. Gene analysis covers the following areas:
- Gene expression analysis
Gene expression is the process by which a gene’s DNA sequence is converted into gene product – the biochemical material, either RNA or protein. The amount of the protein that cell expresses depends on the physical conditions (temperature, radiation), chemical conditions (toxic pollution, drugs), and biological conditions (during normal state and during disease). The expression analysis of the thousands of genes allows for identification of disease state, for instance cancer, and application of appropriate treatment. The analysis of relation between gene expression and the particular chemical substances in terms of toxicity allows for development of new drugs.
- Gene coregulation analysis
Regulation of gene expression is the cellular control of the amount and timing of appearance of gene product. The aim of coregulation analysis is to identify these genes whose regulation of gene expression are similar. Two genes with similar regulation profiles tend to perform similar functions. The experiments based on micro arrays can identify new function of a gene.
- Gene regulatory network
Genes can be viewed as nodes in a complex network, with input being proteins and output being the level of gene espression. The behavior of the particular gene depends on the activity of the other genes. The identification of gene regulatory network is equivalent to identification of genes that regulate the activity of other genes which in turn regulate the cellular behavior.
- Clinical diagnosis
The analysis of gene expression can facilitate the process of clinical diagnosis. The diagnosis can be made using the data base of organ expression response to a particular disease.
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